Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins?
نویسندگان
چکیده
منابع مشابه
The multifunctional or moonlighting protein CD26/DPPIV.
CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional protein that exerts its different functions depending on cell type and intra- or extracellular conditions in which it is expressed. In the present review, we summarize all its known functions in relation to physiological and pathophysiological conditions. The protein is a proteolytic enzyme, receptor, costimulat...
متن کاملDo Moonlighting Proteins Belong to the Intrinsically Disordered Protein Class?
Moonlighting proteins refer to those proteins presenting two or more functions performed by a single polypeptide chain. They were initially reported by Wistow and Piatigorsky in the late 1980s when lens crystallins turned out to be previously known metabolic enzymes [1,2]. Moonlighting proteins present alternative functions which are mostly related to cellular localization, cell type, oligomeri...
متن کاملBioinformatics and Moonlighting Proteins
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. In the present work, we analyze and descr...
متن کاملWhy study moonlighting proteins?
Moonlighting proteins comprise a class of multifunctional proteins in which a single protein performs multiple physiologically relevant biochemical or biophysical functions that are not due to gene fusions, multiple RNA splice variants, or pleiotropic effects (Jeffery, 1999). Classic examples include soluble enzymes that also bind to DNA or RNA to regulate translation or transcription (Figure 1...
متن کاملMoonlighting proteins in yeasts.
Proteins able to participate in unrelated biological processes have been grouped under the generic name of moonlighting proteins. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell. Moonlighting activities in yeasts include such diverse functions as control of gene expression, organelle as...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2003
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg111